Technology Process of 1,4-Dimethyl-2-oxo-3-cyclohexeneacetic acid
There total 8 articles about 1,4-Dimethyl-2-oxo-3-cyclohexeneacetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
ethanol; water;
for 15.5h;
Ambient temperature;
DOI:10.1021/jo01309a003
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) 1,2-dimethoxyethane , Ethanol heat for 14.5 h; 2.) 15 min,0 deg C
2: 1.) O3; 2.) Zn,50percentHOAc / 1.) CH2Cl2,- 78 deg C; 2.) reflux
3: 79 percent / Jones reagent / acetone
4: 95 percent / K2CO3 / acetone / 2 h / Heating
5: 97 percent / Br2 / acetic acid; acetic acid / 6.5 h
6: 91 percent / CaCO3 / N,N-dimethyl-acetamide / 0.75 h / Heating
7: 95 percent / KOH / H2O; ethanol / 15.5 h / Ambient temperature
With
potassium hydroxide; jones reagent; bromine; potassium carbonate; ozone; acetic acid; calcium carbonate; zinc;
In
ethanol; N,N-dimethyl acetamide; water; acetic acid; acetone;
DOI:10.1021/jo01309a003
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) O3; 2.) Zn,50percentHOAc / 1.) CH2Cl2,- 78 deg C; 2.) reflux
2: 79 percent / Jones reagent / acetone
3: 95 percent / K2CO3 / acetone / 2 h / Heating
4: 97 percent / Br2 / acetic acid; acetic acid / 6.5 h
5: 91 percent / CaCO3 / N,N-dimethyl-acetamide / 0.75 h / Heating
6: 95 percent / KOH / H2O; ethanol / 15.5 h / Ambient temperature
With
potassium hydroxide; jones reagent; bromine; potassium carbonate; ozone; acetic acid; calcium carbonate; zinc;
In
ethanol; N,N-dimethyl acetamide; water; acetic acid; acetone;
DOI:10.1021/jo01309a003
