di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate

Base Information

Chemical Name:di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate
CAS No.:1015060-14-6
Molecular Formula:C₂₆H₃₄ClN₅O₇
Molecular Weight:564.038
Hs Code.:

Synonyms:di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate

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Chemical Property of di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate

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Technology Process of di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate

There total 7 articles about di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1015060-11-3
di-tert-butyl {4-chloro-3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl}imide dicarbonate

: 1015060-14-6
di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; at 20 ℃; for 16h;

Reference yield:

: 5604-46-6
2-amino-4,6-dichloropyrimidine-5-carboxaldehyde

: 1015060-14-6
di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium iodide; zinc; indium / N,N-dimethyl-formamide / 3 h

2: water; 4-methylmorpholine N-oxide / osmium(VIII) oxide / tetrahydrofuran; acetone / 48 h / 20 °C

3: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 14 h / 20 °C

4: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C

5: triethylamine / dichloromethane / 17.5 h / Cooling with ice

6: dmap / tetrahydrofuran / 12 h / 20 °C

7: copper(II) choride dihydrate / acetonitrile / 2 h / 20 °C

With dmap; indium; copper(II) choride dihydrate; water; acetic anhydride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; sodium iodide; zinc; osmium(VIII) oxide; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: C₈H₁₁Cl₂N₃O₃

: 1015060-14-6
di-tert-butyl [4-chloro-3-(2,3-dihydroxypropyl)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]imide dicarbonate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 14 h / 20 °C

2: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C

3: triethylamine / dichloromethane / 17.5 h / Cooling with ice

4: dmap / tetrahydrofuran / 12 h / 20 °C

5: copper(II) choride dihydrate / acetonitrile / 2 h / 20 °C

With dmap; copper(II) choride dihydrate; acetic anhydride; dimethyl sulfoxide; triethylamine; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;