Technology Process of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl phenyl ketone
There total 5 articles about 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl phenyl ketone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bromobenzene;
With
magnesium;
In
tetrahydrofuran;
5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl-N-methoxy-N-methylamide;
In
tetrahydrofuran; diethyl ether;
at 20 ℃;
for 22h;
With
water; ammonium chloride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1016/j.bmc.2009.04.044
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / toluene / 24 h / 20 °C
2.1: sodium hydroxide; pyridine; potassium permanganate / 5 h / 95 °C
3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C
4.1: triethylamine / dichloromethane / 17 h / 20 °C
5.1: iodine; magnesium / tetrahydrofuran / 80 °C
5.2: 22 h / 20 °C
With
pyridine; potassium permanganate; oxalyl dichloride; iodine; magnesium; triethylamine; sodium hydroxide;
aluminum (III) chloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; pyridine; potassium permanganate / 5 h / 95 °C
2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C
3.1: triethylamine / dichloromethane / 17 h / 20 °C
4.1: iodine; magnesium / tetrahydrofuran / 80 °C
4.2: 22 h / 20 °C
With
pyridine; potassium permanganate; oxalyl dichloride; iodine; magnesium; triethylamine; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
