(4-chlorophenyl)(2,6-difluorophenyl)methanone

Base Information

Chemical Name:(4-chlorophenyl)(2,6-difluorophenyl)methanone
CAS No.:1094417-01-2
Molecular Formula:C₁₃H₇ClF₂O
Molecular Weight:252.648
Hs Code.:

Synonyms:(4-chlorophenyl)(2,6-difluorophenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-chlorophenyl)(2,6-difluorophenyl)methanone

Chemical Property:

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Technology Process of (4-chlorophenyl)(2,6-difluorophenyl)methanone

There total 2 articles about (4-chlorophenyl)(2,6-difluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 372-18-9
1,3-Difluorobenzene

: 104-88-1
4-chlorobenzaldehyde

: 1094417-01-2
(4-chlorophenyl)(2,6-difluorophenyl)methanone

Guidance literature:: 1,3-Difluorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

4-chlorobenzaldehyde; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h;

With iodine; potassium carbonate; In tert-butyl alcohol; for 18h; Reflux;
DOI:10.1016/j.tet.2011.12.023

Reference yield:

: C₁₂H₆F₄Zn

: 122-01-0
4-chloro-benzoyl chloride

: 1094417-01-2
(4-chlorophenyl)(2,6-difluorophenyl)methanone

Guidance literature:: With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; at -40 - 25 ℃; for 12h; Schlenk technique; Inert atmosphere;
DOI:10.1002/adsc.201300049

Reference yield:

: 52711-30-5
1-bromo-2-(methoxymethyl)benzene

: 1094417-01-2
(4-chlorophenyl)(2,6-difluorophenyl)methanone

: (4-chlorophenyl)(2,6-difluorophenyl)(2-(methoxymethyl)phenyl)methanol

Guidance literature:: 1-bromo-2-(methoxymethyl)benzene; With iodine; magnesium; In tetrahydrofuran; at 60 ℃; for 2h; Inert atmosphere;

(4-chlorophenyl)(2,6-difluorophenyl)methanone; In tetrahydrofuran; at 60 ℃; for 6.33333h;
DOI:10.1039/d1gc02297k