3-(4-cyclohexyloxyphenyl)-4-cyclopropyl-2-hydroxy-4-oxobutyric acid ethyl ester

Base Information

Chemical Name:3-(4-cyclohexyloxyphenyl)-4-cyclopropyl-2-hydroxy-4-oxobutyric acid ethyl ester
CAS No.:1331776-51-2
Molecular Formula:C₂₁H₂₈O₅
Molecular Weight:360.45
Hs Code.:

Synonyms:3-(4-cyclohexyloxyphenyl)-4-cyclopropyl-2-hydroxy-4-oxobutyric acid ethyl ester

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Chemical Property of 3-(4-cyclohexyloxyphenyl)-4-cyclopropyl-2-hydroxy-4-oxobutyric acid ethyl ester

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Technology Process of 3-(4-cyclohexyloxyphenyl)-4-cyclopropyl-2-hydroxy-4-oxobutyric acid ethyl ester

There total 5 articles about 3-(4-cyclohexyloxyphenyl)-4-cyclopropyl-2-hydroxy-4-oxobutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924-44-7
glyoxylic acid ethyl ester

: 1331776-50-1
2-(4-cyclohexyloxy-phenyl)-1-cyclopropylethanone

: 1331776-51-2
3-(4-cyclohexyloxyphenyl)-4-cyclopropyl-2-hydroxy-4-oxobutyric acid ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; toluene; for 12h;

Reference yield:

: 108-93-0
cyclohexanol

: 1331776-51-2
3-(4-cyclohexyloxyphenyl)-4-cyclopropyl-2-hydroxy-4-oxobutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: di-isopropyl azodicarboxylate / triphenylphosphine / tetrahydrofuran / 0.83 h / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran; methanol

3.1: oxalyl dichloride / dichloromethane / 12 h / 0 °C

3.2: 12 h / 0 °C

4.1: diethyl ether; tetrahydrofuran / 1.08 h / -78 °C

5.1: triethylamine / toluene; tetrahydrofuran / 12 h

With oxalyl dichloride; di-isopropyl azodicarboxylate; water; triethylamine; sodium hydroxide; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1331776-51-2
3-(4-cyclohexyloxyphenyl)-4-cyclopropyl-2-hydroxy-4-oxobutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: di-isopropyl azodicarboxylate / triphenylphosphine / tetrahydrofuran / 0.83 h / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran; methanol

3.1: oxalyl dichloride / dichloromethane / 12 h / 0 °C

3.2: 12 h / 0 °C

4.1: diethyl ether; tetrahydrofuran / 1.08 h / -78 °C

5.1: triethylamine / toluene; tetrahydrofuran / 12 h

With oxalyl dichloride; di-isopropyl azodicarboxylate; water; triethylamine; sodium hydroxide; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;