[4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester

Base Information

Chemical Name:[4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester
CAS No.:1159358-87-8
Molecular Formula:C₂₃H₂₆Cl₂N₂O₃
Molecular Weight:449.377
Hs Code.:

Synonyms:[4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester

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Chemical Property of [4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester

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Technology Process of [4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester

There total 12 articles about [4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936098-53-2
tert-butyl (3S)-4-[(4-chlorophenyl)acetyl]-3-methylpiperazine-1-carboxylate

: C₁₁H₁₃ClO₅S

: 1159358-87-8
[4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

Reference yield:

: 936098-44-1
methyl [4-chloro-2-(hydroxymethyl)phenyl]acetate

: (2S)-1-[(4-chlorophenyl)acetyl]-2-methyl-piperazine trifluoroacetate

: 1159358-87-8
[4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester

Guidance literature:: methyl [4-chloro-2-(hydroxymethyl)phenyl]acetate; With methanesulfonyl chloride; triethylamine; In dichloromethane; for 2h; Inert atmosphere;

(2S)-1-[(4-chlorophenyl)acetyl]-2-methyl-piperazine trifluoroacetate; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm1014549

Reference yield:

: 936098-38-3
2-(4-chloro-2-iodophenyl)acetic acid

: 1159358-87-8
[4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane / 48 h / Inert atmosphere

2.1: acetic anhydride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / Inert atmosphere

2.2: 16 h / 80 °C / Inert atmosphere

3.1: borane-THF / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 2 h / Inert atmosphere

4.2: 3 h / 60 °C / Inert atmosphere

With chloro-trimethyl-silane; borane-THF; acetic anhydride; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1014549