Technology Process of methyl [4-chloro-2-(hydroxymethyl)phenyl]acetate
There total 7 articles about methyl [4-chloro-2-(hydroxymethyl)phenyl]acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
borane-THF;
In
tetrahydrofuran;
at 0 - 25 ℃;
Inert atmosphere;
DOI:10.1021/jm1014549
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: chloro-trimethyl-silane / 48 h / Inert atmosphere
2.1: acetic anhydride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / Inert atmosphere
2.2: 16 h / 80 °C / Inert atmosphere
3.1: borane-THF / tetrahydrofuran / 0 - 25 °C / Inert atmosphere
With
chloro-trimethyl-silane; borane-THF; acetic anhydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm1014549
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide / 3 h / 18 - 25 °C / Inert atmosphere
2.1: water; potassium hydroxide / 24 h / 100 °C / Inert atmosphere
3.1: chloro-trimethyl-silane / 48 h / Inert atmosphere
4.1: acetic anhydride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / Inert atmosphere
4.2: 16 h / 80 °C / Inert atmosphere
5.1: borane-THF / tetrahydrofuran / 0 - 25 °C / Inert atmosphere
With
chloro-trimethyl-silane; borane-THF; water; acetic anhydride; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm1014549
