3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}-N-(4-hydroxy-1-isopropylbutyl)propanamide

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Chemical Name:3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}-N-(4-hydroxy-1-isopropylbutyl)propanamide
CAS No.:907190-81-2
Molecular Formula:C₂₉H₃₁Cl₂N₃O₃
Molecular Weight:540.489
Hs Code.:

Synonyms:3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}-N-(4-hydroxy-1-isopropylbutyl)propanamide

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Chemical Property of 3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}-N-(4-hydroxy-1-isopropylbutyl)propanamide

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Technology Process of 3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}-N-(4-hydroxy-1-isopropylbutyl)propanamide

There total 11 articles about 3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}-N-(4-hydroxy-1-isopropylbutyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 907190-80-1
N-(4-{[tert-butyl(diphenyl)silyl]oxy}-1-isopropylbutyl)-3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}propanamide

: 907190-81-2
3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}-N-(4-hydroxy-1-isopropylbutyl)propanamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2006.10.060

Reference yield:

: 907190-73-2
6-{[tert-butyl(diphenyl)silyl]oxy}-2-methylhexan-3-ol

: 907190-81-2
3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}-N-(4-hydroxy-1-isopropylbutyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 0 °C

2: NaN₃ / dimethylformamide / 40 °C

3: H₂ / Pd/C / methanol; ethyl acetate / 20 °C

4: 65 percent / EDCI; DMAP / dimethylformamide / 40 °C

5: 100 percent / TBAF / tetrahydrofuran / 20 °C

With pyridine; dmap; sodium azide; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.10.060

Reference yield:

: 907190-75-4
[(4-azido-5-methylhexyl)oxy](tert-butyl)diphenylsilane

: 907190-81-2
3-{[3-(3,5-dichlorophenyl)-1-(2-naphthyl)-1H-pyrazol-5-yl]oxy}-N-(4-hydroxy-1-isopropylbutyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol; ethyl acetate / 20 °C

2: 65 percent / EDCI; DMAP / dimethylformamide / 40 °C

3: 100 percent / TBAF / tetrahydrofuran / 20 °C

With dmap; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.10.060