ethyl 4-acetyl-1-(4-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: ethyl 4-acetyl-1-(4-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate
• CAS No.: 96734-86-0
• Molecular Formula: C₁₅H₁₅BrN₂O₃
• Molecular Weight: 351.2
• Mol file: 96734-86-0.mol

Synonyms:ethyl 4-acetyl-1-(4-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate

Chemical Property of ethyl 4-acetyl-1-(4-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-acetyl-1-(4-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate

There total 3 articles about ethyl 4-acetyl-1-(4-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethoxycarbonylformyl chloride p-bromophenylhydrazone (27143-10-8) + acetylacetone (123-54-6,81235-32-7) → ethyl 4-acetyl-1-(4-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate (96734-86-0)

Guidance literature:

With sodium ethanolate; In diethyl ether; ethanol; for 15h; Ambient temperature;

Reference yield: 76.0%

ethyl (Z)-2-chloro-2-(2-(4-bromophenyl)hydrazono)acetate (27143-10-8) + acetylacetone (123-54-6,81235-32-7) → ethyl 4-acetyl-1-(4-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate (96734-86-0)

Guidance literature:

With sodium ethanolate; In ethanol;

Reference yield:

4-bromo-aniline (106-40-1) → ethyl 4-acetyl-1-(4-bromophenyl)-5-methyl-1H-pyrazole-3-carboxylate (96734-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium nitrite, 6N HCl; 2.) sodium acetate / 1.) water; 2.) water, ethanol, 0 - 5 deg C, 3 h -> overnight

2: 78 percent / sodium ethoxide / ethanol; diethyl ether / 15 h / Ambient temperature

With hydrogenchloride; sodium ethanolate; sodium acetate; sodium nitrite; In diethyl ether; ethanol;

upstream raw materials:

ethoxycarbonylformyl chloride p-bromophenylhydrazone

acetylacetone

ethyl (Z)-2-chloro-2-(2-(4-bromophenyl)hydrazono)acetate

4-bromo-aniline

Downstream raw materials:

2-(4-Bromo-phenyl)-7-chloro-3,4-dimethyl-2H-pyrazolo[3,4-d]pyridazine

2-(4-Bromo-phenyl)-3,4-dimethyl-6-(4-nitro-phenyl)-2,6-dihydro-pyrazolo[3,4-d]pyridazin-7-one

2-(4-bromophenyl)-3,4-dimethyl-6-phenyl-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-one

2-(4-Bromo-phenyl)-3,4-dimethyl-2,6-dihydro-pyrazolo[3,4-d]pyridazin-7-one