6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

Base Information

Chemical Name:6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride
CAS No.:926319-48-4
Molecular Formula:C₂₈H₃₂N₂O₅*ClH
Molecular Weight:513.033
Hs Code.:

Synonyms:6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

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Chemical Property of 6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

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Technology Process of 6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

There total 18 articles about 6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1-(4-methoxyphenyl)-2-methylpropan-2-yl methanesulfonate

: 8-(R)-(2-amino-1-hydroxyethyl)-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one

: 926319-48-4
6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

Guidance literature:: 1-(4-methoxyphenyl)-2-methylpropan-2-yl methanesulfonate; 8-(R)-(2-amino-1-hydroxyethyl)-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one; With sodium hydrogencarbonate; In tetrahydrofuran; at 45 ℃;

With hydrogenchloride; In ethanol; water; at 20 ℃; for 3h;

Reference yield: 90.0%

: 869478-12-6
8-(2R)-oxirane-6-(phenylmethoxy)-2H-1,4-benzoxazine-3(4H)-one

: 56490-94-9
1-(2-amino-2-methylpropyl)-4-methoxybenzene

: 926319-48-4
6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

Guidance literature:: 8-(2R)-oxirane-6-(phenylmethoxy)-2H-1,4-benzoxazine-3(4H)-one; 1-(2-amino-2-methylpropyl)-4-methoxybenzene; In 1,4-dioxane; at 97 ℃; for 17h;

With hydrogenchloride; In 1,4-dioxane; ethanol; water; at 20 ℃; for 2h;

Reference yield: 55.2%

: 869478-12-6
8-(2R)-oxirane-6-(phenylmethoxy)-2H-1,4-benzoxazine-3(4H)-one

: 56490-93-8
1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride

: 926319-48-4
6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

Guidance literature:: 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride; With sodium hydroxide; In ethyl acetate; at 20 ℃;

8-(2R)-oxirane-6-(phenylmethoxy)-2H-1,4-benzoxazine-3(4H)-one; In 1,4-dioxane; ethyl acetate; at 100 ℃; for 48h;