1-(4-Methoxyphenyl)-2-methylpropan-2-amine hydrochloride

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)-2-methylpropan-2-amine hydrochloride
• CAS No.: 56490-93-8
• Molecular Formula: C11H17 N O . Cl H
• Molecular Weight: 215.723
• European Community (EC) Number: 816-308-0
• DSSTox Substance ID: DTXSID70971910
• Mol file: 56490-93-8.mol

Synonyms:56490-93-8;1-(4-methoxyphenyl)-2-methylpropan-2-amine hydrochloride;Phenethylamine, alpha,alpha-dimethyl-p-methoxy-, hydrochloride;S 65;1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride;1-(4-Methoxyphenyl)-2-methyl-2-propanamine Hydrochloride;1-(4-methoxyphenyl)-2-methylpropan-2-amine HCl;1-(4-methoxyphenyl)-2-methylpropan-2-amine;hydrochloride;Benzeneethanamine, 4-methoxy-alpha,alpha-dimethyl-, hydrochloride;SCHEMBL3800374;DTXSID70971910;AMY16719;AC6367;MFCD01708221;AKOS037654069;KS-7995;SB40417;AC-29949;SY119349;LS-103385;A903469;alpha,alpha-dimethyl-4-methoxyphenethylamine hydrochloride;2-methyl-1-(4-methoxyphenyl)-2-propanamine hydrochloride;Benzeneethanamine,4-methoxy-alpha,alpha-dimethyl-,hydrochloride;1-(4-Methoxyphenyl)-2-methylpropan-2-amine--hydrogen chloride (1/1);Benzeneethanamine, 4-methoxy-.alpha.,.alpha.-dimethyl-, hydrochloride

Chemical Property of 1-(4-Methoxyphenyl)-2-methylpropan-2-amine hydrochloride

Chemical Property:

• Vapor Pressure: 0.00725mmHg at 25°C
• Melting Point: 169 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
• Boiling Point: 269.4°Cat760mmHg
• Flash Point: 110.5°C
• PSA: 60.05000
• Density: g/cm³
• LogP: 2.88090
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 215.1076919
• Heavy Atom Count: 14
• Complexity: 148

Purity/Quality:

98% Min ^*data from raw suppliers

ALPHA,ALPHA-DIMETHYL-PARA-METHOXY-PHENETHYLAMINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CC1=CC=C(C=C1)OC)N.Cl

Technology Process of 1-(4-Methoxyphenyl)-2-methylpropan-2-amine hydrochloride

There total 12 articles about 1-(4-Methoxyphenyl)-2-methylpropan-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(2-amino-2-methylpropyl)-4-methoxybenzene (56490-94-9) → 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride (56490-93-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; tert-butyl methyl ether; at 0 ℃; for 0.5h;

Reference yield: 82.0%

1-(p-aminophenyl)-2-methyl-2-propylamine dihydrochloride (79886-12-7) → 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride (56490-93-8)

Guidance literature:

With hydrogenchloride; sodium nitrite; In methanol; water; 1.) 5 deg C - room temp., 2.) 3 h, reflux;

Reference yield:

1,2-dimethoxyethane (110-71-4) + 1-(4-methoxyphenyl)-1-chloro-2-methyl-2-nitropropane (76072-36-1) → 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride (56490-93-8)

Guidance literature:

With hydrogenchloride; sodium hydroxide; acetic acid; platinum (IV) oxide; In hydrogen; isopropyl alcohol;

upstream raw materials:

1-(p-aminophenyl)-2-methyl-2-propylamine dihydrochloride

C₂₃H₂₆NO₂P

2-(4-nitrobenzyl)-2-nitropropane

4-nitrobenzyl chloride

Downstream raw materials:

6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

Refernces

• 1、 -. "CALCILYTIC COMPOUNDS". Page/Page column 31-32. . Retrieved 2008/12/06.
• 2、 Buchowiecki, Wieslaw,Grosman-Zjawiona, Zofia,Zjawiony, Jordan. "1-DIPHENYLPHOSPHINYL-2,2-DIMETHYLAZIRIDINE - A NEW PRECURSOR OF α,α-DIMETHYLARYLALKYLAMINES". . p. 1245 - 1248. Retrieved 2007/10/02.