(3S)-3-benzyl-4-tert-butyloxycarbonyl-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane

Base Information

Chemical Name:(3S)-3-benzyl-4-tert-butyloxycarbonyl-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane
CAS No.:212612-64-1
Molecular Formula:C₂₆H₃₂N₂O₅
Molecular Weight:452.55
Hs Code.:

Synonyms:(3S)-3-benzyl-4-tert-butyloxycarbonyl-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane

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Chemical Property of (3S)-3-benzyl-4-tert-butyloxycarbonyl-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane

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Technology Process of (3S)-3-benzyl-4-tert-butyloxycarbonyl-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane

There total 9 articles about (3S)-3-benzyl-4-tert-butyloxycarbonyl-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 135884-98-9
(3S)-N-(1'S-benzyl-1'-carbomethoxy)methyl-3-benzyl-1,4-diaza-2-oxocyclohexane

: 212612-64-1
(3S)-3-benzyl-4-tert-butyloxycarbonyl-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane

Guidance literature:: With N-ethylmorpholine;; In dichloromethane; at 0 ℃; Heating;
DOI:10.1021/jo991649t

Reference yield:

: 73270-67-4
(S)-2-allylamino-3-phenyl-propionic acid methyl ester

: 212612-64-1
(3S)-3-benzyl-4-tert-butyloxycarbonyl-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / N-ethylmorpholine / CH₂Cl₂ / 48 h / 20 °C

2.1: O₃ / methanol / 0.58 h / -78 °C

2.2: 88 percent / Me₂S / methanol / -78 - 20 °C

3.1: 83 percent / Et₃SiH; TFA / CH₂Cl₂ / 24 h / 20 °C

4.1: 89 percent / 4-ethylmorpholine / CH₂Cl₂ / 0 °C / Heating

With N-ethylmorpholine;; triethylsilane; ozone; trifluoroacetic acid; In methanol; dichloromethane; 1.1: Acylation / 2.1: Oxidation / 2.2: Cyclization / 3.1: Reduction / 4.1: Substitution;
DOI:10.1021/jo991649t

Reference yield:

: 203873-71-6
N-allyl-tert-butyloxycarbonyl-L-phenylalaninyl-L-phenylalanine methyl ester

: 212612-64-1
(3S)-3-benzyl-4-tert-butyloxycarbonyl-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1.1: O₃ / methanol / 0.58 h / -78 °C

1.2: 88 percent / Me₂S / methanol / -78 - 20 °C

2.1: 83 percent / Et₃SiH; TFA / CH₂Cl₂ / 24 h / 20 °C

3.1: 89 percent / 4-ethylmorpholine / CH₂Cl₂ / 0 °C / Heating

With N-ethylmorpholine;; triethylsilane; ozone; trifluoroacetic acid; In methanol; dichloromethane; 1.1: Oxidation / 1.2: Cyclization / 2.1: Reduction / 3.1: Substitution;
DOI:10.1021/jo991649t