methyl 3-phenyl-3-(2'-oxo-3'-benzyl-1'-piperazinyl)propionate

Base Information

Chemical Name:methyl 3-phenyl-3-(2'-oxo-3'-benzyl-1'-piperazinyl)propionate
CAS No.:135884-98-9
Molecular Formula:C21H24 N2 O3
Molecular Weight:352.433
Hs Code.:
Mol file:135884-98-9.mol

Synonyms:1-Piperazineaceticacid, 2-oxo-a,3-bis(phenylmethyl)-,methyl ester, [S-(R*,R*)]-

Suppliers and Price of methyl 3-phenyl-3-(2'-oxo-3'-benzyl-1'-piperazinyl)propionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl 3-phenyl-3-(2'-oxo-3'-benzyl-1'-piperazinyl)propionate

Chemical Property:

Boiling Point:543.2°Cat760mmHg
Flash Point:282.3°C
PSA：58.64000
Density:1.17g/cm³
LogP:2.08050

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methyl 3-phenyl-3-(2'-oxo-3'-benzyl-1'-piperazinyl)propionate

There total 9 articles about methyl 3-phenyl-3-(2'-oxo-3'-benzyl-1'-piperazinyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 270257-61-9
(3S)-3-benzyl-4-tert-butyloxycarbonyl-5-hydroxy-1-(1'S-benzyl-1'-carbomethoxy)methyl-1,4-diaza-2-oxocyclohexane

: 135884-98-9
(3S)-N-(1'S-benzyl-1'-carbomethoxy)methyl-3-benzyl-1,4-diaza-2-oxocyclohexane

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(98)00289-3

Reference yield:

: 73270-67-4
(S)-2-allylamino-3-phenyl-propionic acid methyl ester

: 135884-98-9
(3S)-N-(1'S-benzyl-1'-carbomethoxy)methyl-3-benzyl-1,4-diaza-2-oxocyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 75 percent / N-ethylmorpholine / CH₂Cl₂ / 48 h / 20 °C

2.1: O₃ / methanol / 0.58 h / -78 °C

2.2: 88 percent / Me₂S / methanol / -78 - 20 °C

3.1: 83 percent / Et₃SiH; TFA / CH₂Cl₂ / 24 h / 20 °C

With N-ethylmorpholine;; triethylsilane; ozone; trifluoroacetic acid; In methanol; dichloromethane; 1.1: Acylation / 2.1: Oxidation / 2.2: Cyclization / 3.1: Reduction;
DOI:10.1021/jo991649t

Reference yield:

: 203873-71-6
N-allyl-tert-butyloxycarbonyl-L-phenylalaninyl-L-phenylalanine methyl ester

: 135884-98-9
(3S)-N-(1'S-benzyl-1'-carbomethoxy)methyl-3-benzyl-1,4-diaza-2-oxocyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₃ / methanol / 0.58 h / -78 °C

1.2: 88 percent / Me₂S / methanol / -78 - 20 °C

2.1: 83 percent / Et₃SiH; TFA / CH₂Cl₂ / 24 h / 20 °C

With triethylsilane; ozone; trifluoroacetic acid; In methanol; dichloromethane; 1.1: Oxidation / 1.2: Cyclization / 2.1: Reduction;
DOI:10.1021/jo991649t