(E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-3'-(4-methoxyphenyl)-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine

Base Information

Chemical Name:(E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-3'-(4-methoxyphenyl)-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine
CAS No.:97060-64-5
Molecular Formula:C₁₈H₂₅NO₃
Molecular Weight:303.401
Hs Code.:

Synonyms:(E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-3'-(4-methoxyphenyl)-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-3'-(4-methoxyphenyl)-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine

Chemical Property:

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Technology Process of (E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-3'-(4-methoxyphenyl)-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine

There total 3 articles about (E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-3'-(4-methoxyphenyl)-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4553-05-3
1-pyrrolidin-1-yl-propan-1-one

: 97060-29-2
1-(4-methoxyphenyl)-but-2-en-1-one

: 97060-65-6,97060-66-7,122968-62-1,122969-99-7
(2'RS,3'RS)- and (2'RS,3'SR)-1-(2',3'-dimethyl-5'-(4-methoxyphenyl)-1',5'-dioxopentyl)pyrrolidine

: 97060-64-5
(E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-3'-(4-methoxyphenyl)-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at 25 ℃; for 19h; Yield given. Yields of byproduct given;
DOI:10.1021/jo00288a027

Reference yield:

: 122969-82-8
3-hydroxy-1-(4-methoxyphenyl)-butan-1-one

: 97060-64-5
(E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-3'-(4-methoxyphenyl)-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) MsCl 2) Et₃N

2: LDA / tetrahydrofuran / 1 h / -78 °C

With methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00288a027

Reference yield:

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 97060-64-5
(E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-hydroxy-3'-(4-methoxyphenyl)-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1) LDA / 1) THF, hexane, -78 deg C 2) -78 deg C

2: 1) MsCl 2) Et₃N

3: LDA / tetrahydrofuran / 1 h / -78 °C

With methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00288a027