Technology Process of methyl D-2-benzamido-4-(3-pyridyl)butyrate
There total 5 articles about methyl D-2-benzamido-4-(3-pyridyl)butyrate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
methanol;
at 37 ℃;
for 3h;
α-chymotrypsin, 0.2M-ammonium acetate buffer at pH 7.8;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 17 g / ammonium chloride / diethyl ether; H2O / 1.) 0 deg C, 4 h; 2.) 50 deg C, 7.5 h
2: 12M aq. hydrochloric acid / 1.) 64 h, room temperature; 2.) 30 h, reflux temperature
3: 91 percent / 1,1,3,3-tetramethylguanidine / dimethylformamide / 48 h / Ambient temperature
4: 97 percent / thionyl chloride / 1.) -10 deg C, 20 min; 2.) allowed to warm, 1 h
5: 96 percent / methanol / 3 h / 37 °C / α-chymotrypsin, 0.2M-ammonium acetate buffer at pH 7.8
With
hydrogenchloride; thionyl chloride; ammonium chloride; N,N,N',N'-tetramethylguanidine;
In
methanol; diethyl ether; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 12M aq. hydrochloric acid / 1.) 64 h, room temperature; 2.) 30 h, reflux temperature
2: 91 percent / 1,1,3,3-tetramethylguanidine / dimethylformamide / 48 h / Ambient temperature
3: 97 percent / thionyl chloride / 1.) -10 deg C, 20 min; 2.) allowed to warm, 1 h
4: 96 percent / methanol / 3 h / 37 °C / α-chymotrypsin, 0.2M-ammonium acetate buffer at pH 7.8
With
hydrogenchloride; thionyl chloride; N,N,N',N'-tetramethylguanidine;
In
methanol; N,N-dimethyl-formamide;
