(3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate

Base Information

Chemical Name:(3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate
CAS No.:1321531-23-0
Molecular Formula:C₃₁H₄₅N₃O₇S
Molecular Weight:603.78
Hs Code.:

(3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate

Synonyms:(3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate

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Chemical Property of (3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate

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Technology Process of (3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate

There total 5 articles about (3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1321531-13-8
(3aS,5R,6aR)-3-oxohexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]carbamate

: 124-40-3
dimethyl amine

: 1321531-23-0
(3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate

Guidance literature:: (3aS,5R,6aR)-3-oxohexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]carbamate; dimethyl amine; With acetic acid; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In acetonitrile; at 0 - 20 ℃; for 72h; Inert atmosphere;
DOI:10.1021/jm200649p

Reference yield:

: 1079393-55-7
(3aS,5R,6aR)-5-(tert-butyldimethyl-silanyloxy)-tetrahydro-2H-cyclopenta[b]furan-3-one

: 1321531-23-0
(3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; pyridine hydrogenfluoride / acetonitrile / 4 h / 0 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: pyridine; trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.2: 36 h / 0 °C / Inert atmosphere

4.1: acetic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

4.2: 72 h / 0 - 20 °C / Inert atmosphere

With pyridine; pyridine hydrogenfluoride; acetic acid; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm200649p

Reference yield:

: 1321531-30-9
(3aS,5R,6aR)-3-oxohexahydro-2H-cyclopenta[b]furan-5-yl(4-nitrophenyl)carbonate

: 1321531-23-0
(3S,3aR,5R,6aR)-3-(dimethylamino)hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3R)-3-Hydroxy-4-(N-iso-butyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl]-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

1.2: 36 h / 0 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

2.2: 72 h / 0 - 20 °C / Inert atmosphere

With pyridine; acetic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm200649p