5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine

Base Information

Chemical Name:5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine
CAS No.:1421687-39-9
Molecular Formula:C₂₁H₂₃ClN₆
Molecular Weight:394.907
Hs Code.:

Synonyms:5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine

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Chemical Property of 5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine

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Technology Process of 5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine

There total 4 articles about 5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159430-52-1
5-(1-piperazinyl)-3(2H)-pyridazinone

: 1421687-39-9
5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile; N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2: trichlorophosphate; pyridine / 2 h / 110 °C / Inert atmosphere

3: pyridine; hydrazine / 0.5 h / 180 °C / Inert atmosphere; Sealed tube

With pyridine; N-ethyl-N,N-diisopropylamine; hydrazine; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml300321d

Reference yield:

: 1421687-38-8
3-chloro-5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)pyridazine

: 1421687-39-9
5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine

Guidance literature:: With pyridine; hydrazine; at 180 ℃; for 0.5h; Inert atmosphere; Sealed tube;
DOI:10.1021/ml300321d

Reference yield:

: 1274804-87-3
4’-chloro-2-iodomethyl-biphenyl

: 1421687-39-9
5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile; N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2: trichlorophosphate; pyridine / 2 h / 110 °C / Inert atmosphere

3: pyridine; hydrazine / 0.5 h / 180 °C / Inert atmosphere; Sealed tube

With pyridine; N-ethyl-N,N-diisopropylamine; hydrazine; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml300321d