153276-34-7Relevant academic research and scientific papers
PYRIDAZINONES AND METHODS OF USE THEREOF
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Page/Page column 118; 119, (2019/04/11)
Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).
The discovery of a selective, small molecule agonist for the mas-related gene X1 receptor
Wroblowski, Berthold,Wigglesworth, Mark J.,Szekeres, Philip G.,Smith, Graham D.,Rahman, Shahzad S.,Nicholson, Neville H.,Muir, Alison I.,Hall, Adrian,Heer, Jag P.,Garland, Stephen L.,Coates, William J.
experimental part, p. 818 - 825 (2009/12/03)
The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain. Here we describe the discovery and optimization of a small molecule agonist and initial docking s
New pyridazinones: Synthesis and correlation between structure and α-blocking activity
Corsano,Scapicchi,Strappaghetti,Marucci,Paparelli
, p. 647 - 651 (2007/10/02)
The synthesis of a series of 5-(4-piperazinyl)-3(2H)-pyridazinone has been reported. The blocking activity of these compounds was determined on the pre- and postsynaptic α-adrenoreceptors of isolated rat vas deferens.
