4-nitrososulfopyridine

Base Information

• Chemical Name: 4-nitrososulfopyridine
• CAS No.: 1202816-93-0
• Molecular Formula: C₁₁H₉N₃O₃S
• Molecular Weight: 263.277
• Mol file: 1202816-93-0.mol

Synonyms:4-nitrososulfopyridine

Chemical Property of 4-nitrososulfopyridine

Chemical Property:

• Melting Point: 150 °C
• Boiling Point: 464.8±51.0 °C(Predicted)
• Density: 1.42±0.1 g/cm3(Predicted)

Purity/Quality:

99.3% ^*data from raw suppliers

4-Nitroso-N-2-pyridinylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Nitroso-N-2-pyridinylbenzenesulfonamide is an intermediate in the synthesis of Sulfasalazine (S699084) related metabolites and derivatives.

Technology Process of 4-nitrososulfopyridine

There total 4 articles about 4-nitrososulfopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H11N3O3S (137525-83-8) → 4-nitrososulfopyridine (1202816-93-0)

Guidance literature:

With iron(III) chloride; In ethanol; water; at 20 ℃; for 0.5h;

DOI:10.1021/tx900329b

Reference yield:

2-aminopyridine (504-29-0) → 4-nitrososulfopyridine (1202816-93-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 24 h / 0 °C

2: hydrazine / ethanol; 1,2-dichloro-ethane / 3 h / 0 - 10 °C

3: iron(III) chloride / ethanol; water / 0.5 h / 20 °C

With pyridine; iron(III) chloride; hydrazine; In ethanol; water; 1,2-dichloro-ethane;

DOI:10.1021/tx900329b

Reference yield:

4-nitro-N-(pyridin-2-yl)benzenesulfonamide (1028-11-1) → 4-nitrososulfopyridine (1202816-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / ethanol; 1,2-dichloro-ethane / 3 h / 0 - 10 °C

2: iron(III) chloride / ethanol; water / 0.5 h / 20 °C

With iron(III) chloride; hydrazine; In ethanol; water; 1,2-dichloro-ethane;

DOI:10.1021/tx900329b

upstream raw materials:

C₁₁H₁₁N₃O₃S

2-aminopyridine

4-nitro-N-(pyridin-2-yl)benzenesulfonamide

4-Nitrobenzenesulfonyl chloride

Downstream raw materials:

sulfosalazine