4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone

Base Information

Chemical Name:4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone
CAS No.:1422457-72-4
Molecular Formula:C₁₅H₁₈F₃NO₃
Molecular Weight:317.308
Hs Code.:

Synonyms:4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone

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Chemical Property of 4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone

Chemical Property:

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Technology Process of 4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone

There total 5 articles about 4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422457-71-3
2-[2-(1,4-dioxaspiro[4.5]dec-8-yloxy)-6-(trifluoromethyl)pyridin-4-yl]propan-2-ol

: 1422457-72-4
4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone

Guidance literature:: 2-[2-(1,4-dioxaspiro[4.5]dec-8-yloxy)-6-(trifluoromethyl)pyridin-4-yl]propan-2-ol; With hydrogenchloride; water; In acetone; at 25 ℃; for 19h;

With sodium hydrogencarbonate; In water; acetone;

Reference yield:

: 22428-87-1
4,4-ethylenedioxycyclohexan-1-ol

: 1422457-72-4
4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 60.5 h / 0 - 25 °C

2: hydrogenchloride; water / acetone / 19 h / 25 °C

With hydrogenchloride; water; sodium hydride; In tetrahydrofuran; acetone; mineral oil;

Reference yield:

: 1196154-43-4
ethyl 2-chloro-6-(trifluoromethyl)isonicotinate

: 1422457-72-4
4-{[4-(1-hydroxy-1-methylethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 3 h / -78 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 60.5 h / 0 - 25 °C

3: hydrogenchloride; water / acetone / 19 h / 25 °C

With hydrogenchloride; water; sodium hydride; In tetrahydrofuran; diethyl ether; acetone; mineral oil;