Cyclopropanecarboxylicacid, 1-[(ethoxycarbonyl)amino]-2,2-dimethyl-

Base Information

Chemical Name:Cyclopropanecarboxylicacid, 1-[(ethoxycarbonyl)amino]-2,2-dimethyl-
CAS No.:159279-74-0
Molecular Formula:C₉H₁₅NO₄
Molecular Weight:201.222
Hs Code.:
DSSTox Substance ID:DTXSID00438541
Mol file:159279-74-0.mol

Synonyms:159279-74-0;1-(ethoxycarbonylamino)-2,2-dimethylcyclopropane-1-carboxylic acid;Cyclopropanecarboxylic acid, 1-[(ethoxycarbonyl)amino]-2,2-dimethyl- (9CI);Cyclopropanecarboxylicacid, 1-[(ethoxycarbonyl)amino]-2,2-dimethyl-;DTXSID00438541;RLVICSYARRNXGI-UHFFFAOYSA-N

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopropanecarboxylicacid, 1-[(ethoxycarbonyl)amino]-2,2-dimethyl-

Chemical Property:

PSA：79.12000
LogP:1.19020
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:201.10010796
Heavy Atom Count:14
Complexity:274

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)NC1(CC1(C)C)C(=O)O

Technology Process of Cyclopropanecarboxylicacid, 1-[(ethoxycarbonyl)amino]-2,2-dimethyl-

There total 5 articles about Cyclopropanecarboxylicacid, 1-[(ethoxycarbonyl)amino]-2,2-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 159279-67-1
1-Ethoxycarbonylamino-2,2-dimethyl-cyclopropanecarboxylic acid methyl ester

: 159279-74-0
1-(N-(Ethoxycarbonyl)amino)-2,2-dimethylcyclopropanecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; 1.) reflux, 2 h, 2.) r.t., 1 d;
DOI:10.1021/jo00105a045

Reference yield: 71.0%

: 541-41-3
chloroformic acid ethyl ester

: 123445-53-4
(+/-)-2,2-dimethyl-1-aminocyclopropane-1-carboxylic acid

: 159279-74-0
1-(N-(Ethoxycarbonyl)amino)-2,2-dimethylcyclopropanecarboxylic acid

Guidance literature:: With pyridine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jo00102a022

Reference yield:

: 18795-95-4
dimethyl 2,2-dimethyl-cyclopropane-1,1-dicarboxylate

: 159279-74-0
1-(N-(Ethoxycarbonyl)amino)-2,2-dimethylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / 1 N NaOH / methanol / 15 h / Ambient temperature

2: Et₃N, diphenyl phosphoroazidate / toluene / 1 h / Heating

3: toluene / 20 h / Ambient temperature

4: 97 percent / 1 N NaOH / methanol / 1.) reflux, 2 h, 2.) r.t., 1 d

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; In methanol; toluene;
DOI:10.1021/jo00105a045