(S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate

Base Information

• Chemical Name: (S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate
• CAS No.: 1560797-70-7
• Molecular Formula: C₄H₆O₆*C₃₁H₄₃ClN₂O₃
• Molecular Weight: 677.235
• Mol file: 1560797-70-7.mol

Synonyms:(S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate

Chemical Property of (S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate

There total 5 articles about (S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Tartaric acid (87-69-4,138508-61-9) + (RS)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butyric acid D-menthyl ester (1560797-65-0) → (S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate (1560797-70-7)

Guidance literature:

In [⁽²⁾H₆]acetone; hexane; at 20 ℃; for 15h; Large scale;

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → (S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate (1560797-70-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h / -70 °C / Large scale

1.2: 20 °C / Large scale

2.1: 5 h / 130 °C / Large scale

2.2: 15 h / 80 °C / Large scale

3.1: sodium iodide; potassium carbonate / acetonitrile / 15 h / 80 °C / Large scale

4.1: [⁽²⁾H₆]acetone; hexane / 15 h / 20 °C / Large scale

With potassium carbonate; triethylamine; sodium iodide; In [⁽²⁾H₆]acetone; hexane; dichloromethane; acetonitrile;

Reference yield:

N-acetyl-4-hydroxypiperidine (4045-22-1) → (S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate (1560797-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 5 h / 130 °C / Large scale

1.2: 15 h / 80 °C / Large scale

2.1: sodium iodide; potassium carbonate / acetonitrile / 15 h / 80 °C / Large scale

3.1: [⁽²⁾H₆]acetone; hexane / 15 h / 20 °C / Large scale

With potassium carbonate; sodium iodide; In [⁽²⁾H₆]acetone; hexane; acetonitrile;

upstream raw materials:

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

L-Tartaric acid

(RS)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butyric acid D-menthyl ester

N-acetyl-4-hydroxypiperidine

Downstream raw materials:

(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino] butyric acid D-menthyl ester

Bepotastine

[14C]-Bepotastine besilate