7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline

Base Information

Chemical Name:7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline
CAS No.:47706-26-3
Molecular Formula:C₂₆H₂₈BrNO₄
Molecular Weight:498.417
Hs Code.:

Synonyms:7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline

Chemical Property:

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Technology Process of 7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline

There total 4 articles about 7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58446-74-5
7-benzyloxy-1-(2-bromo-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-isoquinoline

: 47706-26-3
7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline

Guidance literature:: With sodium tetrahydroborate;
DOI:10.1002/ejoc.201101214

Reference yield:

: 4697-62-5
6-bromohomoveratric acid

: 47706-26-3
7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: phosphorus pentachloride / dichloromethane / 13 h / 0 - 20 °C

3.1: sodium tetrahydroborate; methanol / 0 - 20 °C

With methanol; sodium tetrahydroborate; phosphorus pentachloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; 2.1: |Bischler-Napieralski Reaction;
DOI:10.1002/cmdc.201800318

Reference yield:

: 18883-64-2
N-[4-(benzyloxy)-3-methoxyphenethyl]-2-(2-bromo-4,5-dimethoxyphenyl)acetamide

: 47706-26-3
7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

2: sodium tetrahydroborate

With sodium tetrahydroborate; 1: Bischler-Napieralski cyclization;
DOI:10.1002/ejoc.201101214