2(1H)-Isoquinolinecarboxylic acid, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-7-[(ethoxycarbonyl)oxy]-3,4-dihydro-6-methoxy-, ethyl ester

Base Information

• Chemical Name: 2(1H)-Isoquinolinecarboxylic acid, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-7-[(ethoxycarbonyl)oxy]-3,4-dihydro-6-methoxy-, ethyl ester
• CAS No.: 123190-18-1
• Molecular Formula: C25H30 Br N O8
• Molecular Weight: 0
• Mol file: 123190-18-1.mol

Synonyms:2(1H)-Isoquinolinecarboxylicacid,1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-7-[(ethoxycarbonyl)oxy]-3,4-dihydro-6-methoxy-,ethyl ester, (?à)-

Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-7-[(ethoxycarbonyl)oxy]-3,4-dihydro-6-methoxy-, ethyl ester

Chemical Property:

• PSA: 92.76000
• LogP: 5.24650

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-7-[(ethoxycarbonyl)oxy]-3,4-dihydro-6-methoxy-, ethyl ester

There total 2 articles about 2(1H)-Isoquinolinecarboxylic acid, 1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-7-[(ethoxycarbonyl)oxy]-3,4-dihydro-6-methoxy-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.6%

chloroformic acid ethyl ester (541-41-3) + 1-<2'-bromo-4',5'-dimethoxy>-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline (120566-97-4) → 1-(2-bromo-4,5-dimethoxybenzyl)-2-ethoxycarbonyl-1,2,3,4-tetrahydro-7-ethoxycarbonyl-6-methoxyisoquinoline (123190-18-1)

Guidance literature:

With triethylamine; In chloroform; 1.) 10 deg C, 0.5 h, 2.) room temperature, 0.5 h;

Reference yield:

7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline (47706-26-3) → 1-(2-bromo-4,5-dimethoxybenzyl)-2-ethoxycarbonyl-1,2,3,4-tetrahydro-7-ethoxycarbonyl-6-methoxyisoquinoline (123190-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93.5 percent / conc. HCl / ethanol / 3 h / Heating

2: 80.6 percent / Et₃N / CHCl₃ / 1.) 10 deg C, 0.5 h, 2.) room temperature, 0.5 h

With hydrogenchloride; triethylamine; In ethanol; chloroform;

Reference yield: 74.8%

1-(2-bromo-4,5-dimethoxybenzyl)-2-ethoxycarbonyl-1,2,3,4-tetrahydro-7-ethoxycarbonyl-6-methoxyisoquinoline (123190-18-1) → 1-(2-bromo-4,5-dimethoxybenzyl)-2-ethoxycarbonyl-1,2,3,4-tetrahydro-7-hydroxy-6-methoxyisoquinoline (51015-09-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 0.25h; Heating;

upstream raw materials:

chloroformic acid ethyl ester

1-<2'-bromo-4',5'-dimethoxy>-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

7-benzyloxy-1-(2-bromo-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline

Downstream raw materials:

1-(2-bromo-4,5-dimethoxybenzyl)-2-ethoxycarbonyl-1,2,3,4-tetrahydro-7-hydroxy-6-methoxyisoquinoline