2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine

Base Information

Chemical Name:2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine
CAS No.:99796-40-4
Molecular Formula:C₂₄H₂₄ClN₅O₂
Molecular Weight:449.94
Hs Code.:

Synonyms:2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine

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Technology Process of 2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine

There total 5 articles about 2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 99776-39-3
1-(benzyloxy)-2-<(benzyloxy)methyl>-4-chloro-2-butene

: 10310-21-1
2-Amino-6-chloropurin

: 99796-40-4
2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; for 4h; Ambient temperature;
DOI:10.1021/jm00388a036

Reference yield:

: 584-08-7
potassium carbonate

: 99776-39-3
1-(benzyloxy)-2-<(benzyloxy)methyl>-4-chloro-2-butene

: 10310-21-1
2-Amino-6-chloropurin

: 99796-40-4
2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine

Guidance literature:: In N-methyl-acetamide; N,N-dimethyl-formamide;

Reference yield:

: 77356-14-0
1,3-dibenzyloxy-2-propanone

: 99796-40-4
2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) toluene, RT, 2.) toluene, RT, 45 min

2: 68 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / Ambient temperature

3: 66 percent / 4-(dimethylamino)pyridine (DMAP), p-toluenesulfonyl chloride, triethylamine / CH₂Cl₂ / 0.67 h / Ambient temperature

4: 54 percent / K₂CO₃ / dimethylsulfoxide / 4 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00388a036