Imidazo[1,2-B]pyridazine-6-carbaldehyde

Base Information

• Chemical Name: Imidazo[1,2-B]pyridazine-6-carbaldehyde
• CAS No.: 185910-99-0
• Molecular Formula: C7H5 N3 O
• Molecular Weight: 147.1341
• DSSTox Substance ID: DTXSID80444600
• Wikidata: Q82262786
• Mol file: 185910-99-0.mol

Synonyms:IMIDAZO[1,2-B]PYRIDAZINE-6-CARBALDEHYDE;185910-99-0;Imidazo[1,2-b]pyridazine-6-carboxaldehyde;Imidazo[1,2-b]pyridazine-6-carboxaldehyde (9CI);SCHEMBL18041945;DTXSID80444600;MFCD10698053;AKOS006305346;AB61147

Chemical Property of Imidazo[1,2-B]pyridazine-6-carbaldehyde

Chemical Property:

• PSA: 47.26000
• LogP: 0.54180
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 147.043261791
• Heavy Atom Count: 11
• Complexity: 162

Purity/Quality:

98%min ^*data from raw suppliers

Imidazo[1,2-b]pyridazine-6-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=CN2N=C1C=O

Technology Process of Imidazo[1,2-B]pyridazine-6-carbaldehyde

There total 4 articles about Imidazo[1,2-B]pyridazine-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.6%

6-vinylimidazo[1,2-b]pyridazine → imidazo[1,2-b]pyridazine-6-carbaldehyde (185910-99-0)

Guidance literature:

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; at 20 ℃; for 16h;

Reference yield: 48.0%

6-cyanoimidazo[1,2-b]pyridazine (342812-07-1) → imidazo[1,2-b]pyridazine-6-carbaldehyde (185910-99-0)

Guidance literature:

nickel; In formic acid; water; at 100 ℃; for 1h;

DOI:10.7164/antibiotics.54.257

Reference yield:

6-carbamoylimidazo[1,2-b]pyridazine (159045-50-8) → imidazo[1,2-b]pyridazine-6-carbaldehyde (185910-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / POCl₃ / 4.5 h / 115 °C

2: 48 percent / Raney-Ni / formic acid; H₂O / 1 h / 100 °C

With trichlorophosphate; nickel; In formic acid; water;

DOI:10.7164/antibiotics.54.257

upstream raw materials:

6-cyanoimidazo[1,2-b]pyridazine

6-carbamoylimidazo[1,2-b]pyridazine

6-chloroimidazo[1,2-b]pyridazine

Downstream raw materials:

p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates