p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates

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Chemical Name:p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates
CAS No.:185911-03-9
Molecular Formula:C₂₈H₂₉N₅O₆S
Molecular Weight:563.634
Hs Code.:

Synonyms:p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates

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Chemical Property of p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates

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Technology Process of p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates

There total 7 articles about p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 185910-99-0
imidazo[1,2-b]pyridazine-6-carbaldehyde

: p-methoxybenzyl 7β-t-butoxycarbonylamino-3-(triphenylphosphonium)methyl-3-cephem-4-carboxylate iodide

: 185911-03-9
p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates

Guidance literature:: p-methoxybenzyl 7β-t-butoxycarbonylamino-3-(triphenylphosphonium)methyl-3-cephem-4-carboxylate iodide; With sodium hydroxide; sodium chloride; In chloroform; water; at 20 ℃; for 1h;

imidazo[1,2-b]pyridazine-6-carbaldehyde; In chloroform; at 20 ℃; for 5.5h;
DOI:10.7164/antibiotics.54.257

Reference yield:

: 159045-50-8
6-carbamoylimidazo[1,2-b]pyridazine

: 185911-03-9
p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / POCl₃ / 4.5 h / 115 °C

2.1: 48 percent / Raney-Ni / formic acid; H₂O / 1 h / 100 °C

3.1: NaOH; NaCl / H₂O; CHCl₃ / 1 h / 20 °C

3.2: 57 percent / CHCl₃ / 5.5 h / 20 °C

With sodium hydroxide; sodium chloride; trichlorophosphate; nickel; In formic acid; chloroform; water;
DOI:10.7164/antibiotics.54.257

Reference yield:

: 342812-07-1
6-cyanoimidazo[1,2-b]pyridazine

: 185911-03-9
p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates

Guidance literature:: Multi-step reaction with 2 steps

1.1: 48 percent / Raney-Ni / formic acid; H₂O / 1 h / 100 °C

2.1: NaOH; NaCl / H₂O; CHCl₃ / 1 h / 20 °C

2.2: 57 percent / CHCl₃ / 5.5 h / 20 °C

With sodium hydroxide; sodium chloride; nickel; In formic acid; chloroform; water;
DOI:10.7164/antibiotics.54.257