<1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

Base Information

• Chemical Name: <1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide
• CAS No.: 132294-21-4
• Molecular Formula: C₂₆H₃₄N₂O₆
• Molecular Weight: 470.566

Synonyms:<1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

Chemical Property of <1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

There total 2 articles about <1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester (127696-10-0) → <1R-<1α(R*),2β(R*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide (132294-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 2 N KOH / methanol / 1 h / 43 °C

2: DCC / CH₂Cl₂ / Ambient temperature

With potassium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1021/jm00108a026

Reference yield:

D-2-phenylglycinol (56613-80-0) + trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid (132178-71-3) → <1S-<1α(S*),2β(S*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide (132178-72-4) + <1R-<1α(R*),2β(R*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide (132294-21-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jm00108a026

Reference yield:

<1R-<1α(R*),2β(R*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide (132294-21-4) + tert-butyldimethylsilyl chloride (18162-48-6) → (1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide} (132294-29-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 5 ℃; for 1.5h;

DOI:10.1021/jm00108a026

upstream raw materials:

D-2-phenylglycinol

trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid

trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester

Downstream raw materials:

(1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide}

C₃₈H₆₀N₄O₈Si₂

((1R,2R)-3,3-diethoxycyclobutane-1,2-diyl)dimethanol

(1R-trans)-3,3-diethoxy-1,2-cyclobutanedimethanol dibenzoate ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 132294-21-4 <1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send