tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate
CAS No.:1268163-47-8
Molecular Formula:C₃₀H₃₆N₄O₄
Molecular Weight:516.64
Hs Code.:

Synonyms:tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate

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Chemical Property of tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate

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Technology Process of tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate

There total 8 articles about tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 389621-81-2
[4-(pyrrolidin-1-ylcarbonyl)phenyl]boronic acid

: 1268163-47-8
tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 18 h / 100 °C

2.1: toluene / 2.5 h / Reflux

3.1: acetic acid; iron / 4 h / 85 °C

3.2: pH 9 - 10

4.1: dichloromethane / 72 h / 20 °C

5.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 0 - 20 °C

5.2: pH ~ 3.5

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

6.2: 2 h / 20 °C

With water; iron; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 107-10-8,42939-71-9
propylamine

: 1268163-46-7
(1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid

: 1268163-47-8
tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate

Guidance literature:: (1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

propylamine; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 60956-26-5
4-bromo-2-nitrotoluene

: 1268163-47-8
tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: chromium(VI) oxide; sulfuric acid / 0 - 10 °C

2.1: hydrogenchloride / ethanol; water / 0.75 h / Reflux

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 18 h / 100 °C

4.1: toluene / 2.5 h / Reflux

5.1: acetic acid; iron / 4 h / 85 °C

5.2: pH 9 - 10

6.1: dichloromethane / 72 h / 20 °C

7.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 0 - 20 °C

7.2: pH ~ 3.5

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

8.2: 2 h / 20 °C

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; water; iron; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;