3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester

Base Information

• Chemical Name: 3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester
• CAS No.: 869353-35-5
• Molecular Formula: C₁₇H₂₇F₃O₄Si₂
• Molecular Weight: 408.565

Synonyms:3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester

Chemical Property of 3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester

Chemical Property:

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Technology Process of 3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester

There total 3 articles about 3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-methoxy-1-(trimethylsilyloxy)-2-(trifluoromethyl)-2-(trimethylsilyloxy)ethene + benzaldehyde (100-52-7) → 3,3,3-trifluoro-2-[1'-phenyl-1'-hydroxymethyl]-2-(trimethylsilyloxy)propanoic acid methyl ester + 3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester (869353-35-5)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -30 ℃; for 8h;

DOI:10.1021/jo051242q

Reference yield:

1-methoxy-1-(trimethylsilyloxy)-2-(trifluoromethyl)-2-(trimethylsilyloxy)ethene + benzaldehyde (100-52-7) → 3,3,3-trifluoro-2-trimethylsilanyloxy-propionic acid methyl ester + 3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester (869353-35-5) + methyl β,β-difluoro-α-trimethylsilyloxyacrylate (491612-52-3)

Guidance literature:

With zinc(II) iodide; In dichloromethane; at -30 ℃; for 10h; Title compound not separated from byproducts;

DOI:10.1021/jo051242q

Reference yield:

1-methoxy-1-(trimethylsilyloxy)-2-(trifluoromethyl)-2-(trimethylsilyloxy)ethene + benzaldehyde (100-52-7) → 3,3,3-trifluoro-2-hydroxy-2-[1'-phenyl-1'-hydroxymethyl]propanoic acid methyl ester + 3,3,3-trifluoro-2-[1'-phenyl-1'-hydroxymethyl]-2-(trimethylsilyloxy)propanoic acid methyl ester + 3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester (869353-35-5) + methyl β,β-difluoro-α-trimethylsilyloxyacrylate (491612-52-3)

Guidance literature:

With aluminium trichloride; In dichloromethane; at -30 ℃; for 10h;

DOI:10.1021/jo051242q

upstream raw materials:

benzaldehyde

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