2-Propenoic acid, 3,3-difluoro-2-[(trimethylsilyl)oxy]-, methyl ester

Base Information

• Chemical Name: 2-Propenoic acid, 3,3-difluoro-2-[(trimethylsilyl)oxy]-, methyl ester
• CAS No.: 491612-52-3
• Molecular Formula: C7H12F2O3Si
• Molecular Weight: 210.25100
• DSSTox Substance ID: DTXSID40473517
• Nikkaji Number: J1.800.656A
• Mol file: 491612-52-3.mol

Synonyms:491612-52-3;2-Propenoic acid, 3,3-difluoro-2-[(trimethylsilyl)oxy]-, methyl ester;DTXSID40473517

Chemical Property of 2-Propenoic acid, 3,3-difluoro-2-[(trimethylsilyl)oxy]-, methyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 2.11900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 210.05237710
• Heavy Atom Count: 13
• Complexity: 228

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(=C(F)F)O[Si](C)(C)C

Technology Process of 2-Propenoic acid, 3,3-difluoro-2-[(trimethylsilyl)oxy]-, methyl ester

There total 3 articles about 2-Propenoic acid, 3,3-difluoro-2-[(trimethylsilyl)oxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methoxy-1-(trimethylsilyloxy)-2-(trifluoromethyl)-2-(trimethylsilyloxy)ethene + benzaldehyde (100-52-7) → 3,3,3-trifluoro-2-trimethylsilanyloxy-propionic acid methyl ester + 3,3,3-trifluoro-2-[1'-phenyl-1'-hydroxymethyl]-2-(trimethylsilyloxy)propanoic acid methyl ester + methyl β,β-difluoro-α-trimethylsilyloxyacrylate (491612-52-3)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at -30 ℃; for 10h; Title compound not separated from byproducts;

DOI:10.1021/jo051242q

Reference yield:

1-methoxy-1-(trimethylsilyloxy)-2-(trifluoromethyl)-2-(trimethylsilyloxy)ethene + benzaldehyde (100-52-7) → 3,3,3-trifluoro-2-trimethylsilanyloxy-propionic acid methyl ester + 3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester (869353-35-5) + methyl β,β-difluoro-α-trimethylsilyloxyacrylate (491612-52-3)

Guidance literature:

With zinc(II) iodide; In dichloromethane; at -30 ℃; for 10h; Title compound not separated from byproducts;

DOI:10.1021/jo051242q

Reference yield:

1-methoxy-1-(trimethylsilyloxy)-2-(trifluoromethyl)-2-(trimethylsilyloxy)ethene + benzaldehyde (100-52-7) → 3,3,3-trifluoro-2-hydroxy-2-[1'-phenyl-1'-hydroxymethyl]propanoic acid methyl ester + 3,3,3-trifluoro-2-[1'-phenyl-1'-hydroxymethyl]-2-(trimethylsilyloxy)propanoic acid methyl ester + 3,3,3-trifluoro-2-[(phenyl)(trimethylsilyloxy)methyl]-2-(trimethylsilyloxy)propanoic acid methyl ester (869353-35-5) + methyl β,β-difluoro-α-trimethylsilyloxyacrylate (491612-52-3)

Guidance literature:

With aluminium trichloride; In dichloromethane; at -30 ℃; for 10h;

DOI:10.1021/jo051242q

upstream raw materials:

benzaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 491612-52-3 2-Propenoic acid, 3,3-difluoro-2-[(trimethylsilyl)oxy]-, methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send