C₂₃H₂₄F₂N₄O₂

Base Information

Chemical Name:C₂₃H₂₄F₂N₄O₂
CAS No.:1613811-86-1
Molecular Formula:C₂₃H₂₄F₂N₄O₂
Molecular Weight:426.466
Hs Code.:

C<sub>23</sub>H<sub>24</sub>F<sub>2</sub>N<sub>4</sub>O<sub>2</sub>

Synonyms:C₂₃H₂₄F₂N₄O₂

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Chemical Property of C₂₃H₂₄F₂N₄O₂

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Technology Process of C₂₃H₂₄F₂N₄O₂

There total 12 articles about C₂₃H₂₄F₂N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1613721-61-1
C₂₈H₃₂F₂N₄O₄

: 1613811-86-1
C₂₃H₂₄F₂N₄O₂

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1021/jm5013006

Reference yield:

: 24036-52-0
6-bromo-3,4-dihydro-2H-1,4-benzoxazin-3-one

: 1613811-86-1
C₂₃H₂₄F₂N₄O₂

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2 h / 20 °C

2.1: Lawessons reagent / toluene / 3 h / 120 °C

3.1: hydrazine hydrate / ethanol / 20 °C

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 90 °C

5.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 80 °C

5.2: chiralpak AD

6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

7.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 0.5 h / 20 °C

8.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol / 16 h / 90 °C

9.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 90 °C

10.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With Lawessons reagent; hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium acetate; tetra-N-butylammonium tribromide; potassium hexamethylsilazane; sodium carbonate; hydrazine hydrate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 5.1: |Suzuki Coupling;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-91-7
(R)-2-(6-bromo-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613811-86-1
C₂₃H₂₄F₂N₄O₂

Guidance literature:: Multi-step reaction with 9 steps

1.1: Lawessons reagent / toluene / 3 h / 120 °C

2.1: hydrazine hydrate / ethanol / 20 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 90 °C

4.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 80 °C

4.2: chiralpak AD

5.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

6.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 0.5 h / 20 °C

7.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol / 16 h / 90 °C

8.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 90 °C

9.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With Lawessons reagent; hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium acetate; tetra-N-butylammonium tribromide; sodium carbonate; hydrazine hydrate; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/jm5013006