(R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Base Information

Chemical Name:(R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one
CAS No.:1613719-20-2
Molecular Formula:C₂₄H₂₆F₂N₄O₂
Molecular Weight:440.493
Hs Code.:

Synonyms:(R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Suppliers and Price of (R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

There total 12 articles about (R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1613811-86-1
C₂₃H₂₄F₂N₄O₂

: 1613719-20-2
(R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: formaldehyd; C₂₃H₂₄F₂N₄O₂; With acetic acid; In methanol; at 20 ℃; for 1h;

With sodium cyanoborohydride; In methanol;
DOI:10.1021/jm5013006

Reference yield:

: 24036-52-0
6-bromo-3,4-dihydro-2H-1,4-benzoxazin-3-one

: 1613719-20-2
(R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2 h / 20 °C

2.1: Lawessons reagent / toluene / 3 h / 120 °C

3.1: hydrazine hydrate / ethanol / 20 °C

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 90 °C

5.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 80 °C

5.2: chiralpak AD

6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

7.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 0.5 h / 20 °C

8.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol / 16 h / 90 °C

9.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 90 °C

10.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

11.1: acetic acid / methanol / 1 h / 20 °C

With Lawessons reagent; hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium acetate; tetra-N-butylammonium tribromide; potassium hexamethylsilazane; sodium carbonate; hydrazine hydrate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 5.1: |Suzuki Coupling;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-91-7
(R)-2-(6-bromo-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613719-20-2
(R)-7-(2,6-difluorophenyl)-6-((3R,4R)-1,3-dimethylpiperidin-4-yl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: Lawessons reagent / toluene / 3 h / 120 °C

2.1: hydrazine hydrate / ethanol / 20 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 90 °C

4.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 80 °C

4.2: chiralpak AD

5.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

6.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 0.5 h / 20 °C

7.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethanol / 16 h / 90 °C

8.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 90 °C

9.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

10.1: acetic acid / methanol / 1 h / 20 °C

With Lawessons reagent; hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium acetate; tetra-N-butylammonium tribromide; sodium carbonate; hydrazine hydrate; acetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/jm5013006