(R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate

Base Information

• Chemical Name: (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate
• CAS No.: 1104606-06-5
• Molecular Formula: C₂₄H₂₅FN₄O₂
• Molecular Weight: 420.487
• Mol file: 1104606-06-5.mol

Synonyms:(R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate

Chemical Property of (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate

There total 3 articles about (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Boc-D-Trp-OH (5241-64-5) + 2-bromo-4'-fluoroacetophenone (403-29-2) → (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate (1104606-06-5)

Guidance literature:

Boc-D-Trp-OH; With caesium carbonate; In ethanol; at 20 ℃; for 0.5h;

2-bromo-4'-fluoroacetophenone; In N,N-dimethyl-formamide; at 20 ℃;

With ammonium acetate; In para-xylene; for 3h; Reflux;

DOI:10.1021/ml300063m

Reference yield:

C24H25FN2O5 (1411994-50-7) → (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate (1104606-06-5)

Guidance literature:

With ammonium acetate; In toluene; at 110 ℃; for 2.5h;

DOI:10.1021/op300128c

Reference yield:

Boc-D-Trp-OH (5241-64-5) → (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate (1104606-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: ammonium acetate / toluene / 2.5 h / 110 °C

With ammonium acetate; caesium carbonate; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/op300128c

upstream raw materials:

Boc-D-Trp-OH

2-bromo-4'-fluoroacetophenone

C₂₄H₂₅FN₂O₅

Downstream raw materials:

(3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

(1R,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

(1S,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

3-((1S,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-5-methyl-1,2,4-oxadiazole