N'-(2,4-dimethyl-phenyl)-N,N-bis-pyridin-2-ylmethyl-ethane-1,2-diamine

Base Information

• Chemical Name: N'-(2,4-dimethyl-phenyl)-N,N-bis-pyridin-2-ylmethyl-ethane-1,2-diamine
• CAS No.: 769193-64-8
• Molecular Formula: C₂₂H₂₆N₄
• Molecular Weight: 346.475
• Mol file: 769193-64-8.mol

Synonyms:N'-(2,4-dimethyl-phenyl)-N,N-bis-pyridin-2-ylmethyl-ethane-1,2-diamine

Chemical Property of N'-(2,4-dimethyl-phenyl)-N,N-bis-pyridin-2-ylmethyl-ethane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(2,4-dimethyl-phenyl)-N,N-bis-pyridin-2-ylmethyl-ethane-1,2-diamine

There total 4 articles about N'-(2,4-dimethyl-phenyl)-N,N-bis-pyridin-2-ylmethyl-ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-bromo-2,4-dimethylbenzene (583-70-0) + (2-aminoethyl)bis(2-pyridylmethyl)amine (189440-33-3) → N'-(2,4-dimethyl-phenyl)-N,N-bis-pyridin-2-ylmethyl-ethane-1,2-diamine (769193-64-8)

Guidance literature:

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; for 96h; Heating;

DOI:10.1039/b505763a

Reference yield: 38.0%

N-(2,4-dimethyl-phenyl)-N'-pyridin-2-ylmethyl-ethane-1,2-diamine + 2-chloromethylpyridine hydrochloride (6959-47-3) → N'-(2,4-dimethyl-phenyl)-N,N-bis-pyridin-2-ylmethyl-ethane-1,2-diamine (769193-64-8) + [2-(2,4-dimethyl-phenylamino)-ethyl]-tris-pyridin-2-ylmethyl-ammonium; chloride

Guidance literature:

With potassium carbonate; In acetonitrile; at 55 ℃; for 72h;

DOI:10.1039/b505763a

Reference yield:

(N-tosyl-2-aminoethyl)bis(2-picolyl)amine (540470-07-3) → N'-(2,4-dimethyl-phenyl)-N,N-bis-pyridin-2-ylmethyl-ethane-1,2-diamine (769193-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / H₂SO₄ / 72 h / 130 °C

2: 74 percent / NaOtBu; rac-BINAP / Pd₂(dba)3 / toluene / 96 h / Heating

With sulfuric acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene;

DOI:10.1039/b505763a

upstream raw materials:

1-bromo-2,4-dimethylbenzene

(2-aminoethyl)bis(2-pyridylmethyl)amine

2-chloromethylpyridine hydrochloride

(N-tosyl-2-aminoethyl)bis(2-picolyl)amine

Downstream raw materials:

CoCl₂((NC₅H₄CH₂)2NCH₂CH₂NHC₆H₃(CH₃)2)