(1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N₆-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane

Base Information

• Chemical Name: (1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N₆-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane
• CAS No.: 938055-77-7
• Molecular Formula: C₂₆H₂₆N₆O₆S
• Molecular Weight: 550.595

Synonyms:(1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N₆-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane

Chemical Property of (1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N₆-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N₆-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane

There total 5 articles about (1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N₆-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine (938055-76-6) → (1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N6-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane (938055-77-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water;

DOI:10.1080/15257770600793729

Reference yield:

methanesulfonic acid 4-amino-3-benzyloxy-2-methanesulfonyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester → (1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N6-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane (938055-77-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / BSA; TMSOTf / 1,2-dichloro-ethane

2: 99 percent / LiOH / tetrahydrofuran; H₂O

With benzenesulfonamide; lithium hydroxide; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; water; 1,2-dichloro-ethane;

DOI:10.1080/15257770600793729

Reference yield:

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine (938055-75-5) → (1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N6-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane (938055-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / BSA; TMSOTf / 1,2-dichloro-ethane

2: 99 percent / LiOH / tetrahydrofuran; H₂O

With benzenesulfonamide; lithium hydroxide; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; water; 1,2-dichloro-ethane;

DOI:10.1080/15257770600793729

upstream raw materials:

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)-N6-benzoyladenine

1-(2-trifluoroacetylamino-3-O-benzyl-4-C-methanesulfonyloxyrnethyl-5-O-methanesulfonyl-2-deoxy-β-D-ribofuranosyl)thymine

N-benzoyladenine

1-[2-azido-3-O-benzyl-2-deoxy-5-O-methanesulfonyl-4-C-(methanesulfonyloxymethyl)-β-D-erythro-pentofuranosyl]thymine

Downstream raw materials:

C₃₁H₃₄N₆O₈S

[3-(6-amino-purin-9-yl)-7-benzyloxy-2-oxa-5-aza-bicyclo[2.2.1]hept-1-yl]-methanol

benzoic acid 3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2-oxa-5-aza-bicyclo[2.2.1]hept-1-ylmethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 938055-77-7 (1R,3R,4R,7S)-7-benzyloxy-1-methansulfonyloxymethyl-3-(N₆-benzoyladenin-9-yl)-2-oxa-5-aza-bicyclo[2.2.1]heptane

Send

Send

Metric Ton KG G Pound L ML

Send

Send