C₆₂H₇₁NO₁₇

Base Information

• Chemical Name: C₆₂H₇₁NO₁₇
• CAS No.: 1052091-65-2
• Molecular Formula: C₆₂H₇₁NO₁₇
• Molecular Weight: 1102.24
• Mol file: 1052091-65-2.mol

Synonyms:C₆₂H₇₁NO₁₇

Chemical Property of C₆₂H₇₁NO₁₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₂H₇₁NO₁₇

There total 12 articles about C₆₂H₇₁NO₁₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iso-butyl sidechain acid (849213-13-4) + C39H46O12 (1051405-78-7) → C62H71NO17 (1052091-65-2)

Guidance literature:

With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In dichloromethane; toluene; at 20 ℃; for 23h;

Reference yield:

2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel (162375-26-0) → C62H71NO17 (1052091-65-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: dmap / dichloromethane / 3 h / 20 °C

2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 22 h / 20 °C

3.1: sodium tetrahydroborate / methanol; ethanol / 5 h / 0 °C

4.1: dmap / dichloromethane / 15 h / 20 °C

4.2: 0.08 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6.1: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C

7.1: lithium borohydride / tetrahydrofuran / 13.25 h / -13 - 0 °C / ice/water/ammonium chloride bath

8.1: 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide / dichloromethane; toluene / 23 h / 20 °C

With dmap; sodium tetrahydroborate; lithium borohydride; tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; 4-pyrrolidin-1-ylpyridine; 4-methylmorpholine N-oxide; dicyclohexyl-carbodiimide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

Reference yield:

2'-O-(tert-butyldimethylsilyl)paclitaxel (114655-02-6) → C62H71NO17 (1052091-65-2)

Guidance literature:

Multi-step reaction with 10 steps

1.1: hydrazine / Isopropyl acetate / 1 h / 20 °C

2.1: dmap / dichloromethane / 3 h / 20 °C

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 22 h / 20 °C

4.1: sodium tetrahydroborate / methanol; ethanol / 5 h / 0 °C

5.1: dmap / dichloromethane / 15 h / 20 °C

5.2: 0.08 h

6.1: hydrogen fluoride; water / acetonitrile / 0.33 h / 0 °C

6.2: 0.17 h

7.1: pyridine hydrogenfluoride / tetrahydrofuran / 1 h / 20 °C

8.1: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C

9.1: lithium borohydride / tetrahydrofuran / 13.25 h / -13 - 0 °C / ice/water/ammonium chloride bath

10.1: 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide / dichloromethane; toluene / 23 h / 20 °C

With dmap; sodium tetrahydroborate; lithium borohydride; tetrapropylammonium perruthennate; hydrogen fluoride; water; 4-pyrrolidin-1-ylpyridine; pyridine hydrogenfluoride; 4-methylmorpholine N-oxide; dicyclohexyl-carbodiimide; hydrazine; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; Isopropyl acetate; toluene; acetonitrile;

upstream raw materials:

iso-butyl sidechain acid

C₃₉H₄₆O₁₂

2-O-TBDMS-9-α-OH-9-desoxo-10-epi-paclitaxel

C₄₇H₅₃NO₁₄

Downstream raw materials:

C₄₃H₆₁NO₁₅