1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-methylmalonate

Base Information

• Chemical Name: 1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-methylmalonate
• CAS No.: 1440524-48-0
• Molecular Formula: C₁₅H₁₇F₃O₄
• Molecular Weight: 318.293
• Mol file: 1440524-48-0.mol

Synonyms:1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-methylmalonate

Chemical Property of 1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-methylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-methylmalonate

There total 1 articles about 1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-methylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

α-methylmalonate mono-tert-butyl ester (37472-52-9) → 1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-methylmalonate (1440524-48-0)

Guidance literature:

With triethylamine; In dichloromethane; for 15h; Reflux;

DOI:10.1039/c3ob40481a

Reference yield:

1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-methylmalonate (1440524-48-0) + benzyl bromide (100-39-0) → (S)-1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-benzyl-2-methylmalonate (1440524-75-3) + (R)-1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-benzyl-2-methylmalonate

Guidance literature:

With (11bS,11b’S)-2,6-bis(3,4,5-trifluorophenyl)-3,3’,5,5’-tetrahydro-4,4’-spirobi[dinaphtho[2,1-c:1’,2’-e]azepin]-4-ium bromide; potassium hydroxide; In water; toluene; at 0 ℃; for 72h; Overall yield = 87 %; enantioselective reaction;

DOI:10.1039/c3ob40481a

upstream raw materials:

α-methylmalonate mono-tert-butyl ester

Downstream raw materials:

(S)-1-tert-butyl 3-(2,3,4-trifluorobenzyl) 2-benzyl-2-methylmalonate