2-(2,4-difluorophenyl)-1-[methyl(piperidin-4-yl)]amino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol trifluoroacetate

Base Information

• Chemical Name: 2-(2,4-difluorophenyl)-1-[methyl(piperidin-4-yl)]amino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol trifluoroacetate
• CAS No.: 1239175-25-7
• Molecular Formula: C₂HF₃O₂*C₁₇H₂₃F₂N₅O
• Molecular Weight: 465.423

Synonyms:2-(2,4-difluorophenyl)-1-[methyl(piperidin-4-yl)]amino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol trifluoroacetate

Chemical Property of 2-(2,4-difluorophenyl)-1-[methyl(piperidin-4-yl)]amino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol trifluoroacetate

Chemical Property:

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Technology Process of 2-(2,4-difluorophenyl)-1-[methyl(piperidin-4-yl)]amino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol trifluoroacetate

There total 1 articles about 2-(2,4-difluorophenyl)-1-[methyl(piperidin-4-yl)]amino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,4-difluorophenyl)-1-{methyl[1-(tert-butoxycarbonyl)piperidin-4-yl]amino}-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (1239175-22-4) + trifluoroacetic acid (76-05-1) → 2-(2,4-difluorophenyl)-1-[methyl(piperidin-4-yl)]amino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol trifluoroacetate (1239175-25-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2010.09.070

Reference yield: 80.0%

2-(2,4-difluorophenyl)-1-[methyl(piperidin-4-yl)]amino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol trifluoroacetate (1239175-25-7) + 1-bromomethyl-3-chlorobenzene (766-80-3) → 3-{[1-(3-chlorobenzyl)piperidin-4-yl]methylamino}-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol (1239174-94-7)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2010.09.070

Reference yield: 78.1%

2-(2,4-difluorophenyl)-1-[methyl(piperidin-4-yl)]amino-3-(1H-1,2,4-triazol-1-yl)propan-2-ol trifluoroacetate (1239175-25-7) + 2,4-dichlorobenzyl bromide (20443-99-6) → 3-{[1-(2,4-dichlorobenzyl)piperidin-4-yl]methylamino}-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol (1239174-90-3)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2010.09.070

upstream raw materials:

2-(2,4-difluorophenyl)-1-{methyl[1-(tert-butoxycarbonyl)piperidin-4-yl]amino}-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

trifluoroacetic acid

Downstream raw materials:

3-{[1-(2-fluorobenzyl)piperidin-4-yl]methylamino}-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

3-{[1-(3-bromobenzyl)piperidin-4-yl]methylamino}-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

3-[(1-benzylpiperidin-4-yl)methylamino]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

3-{[1-(4-isopropylbenzyl)piperidin-4-yl]methylamino}-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

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