4,5-Diazaspiro[2.4]hept-4-ene-6-carboxylicacid,6-methyl-,methylester(9CI)

Base Information

• Chemical Name: 4,5-Diazaspiro[2.4]hept-4-ene-6-carboxylicacid,6-methyl-,methylester(9CI)
• CAS No.: 158664-54-1
• Molecular Formula: C8H12 N2 O2
• Molecular Weight: 168.19
• Mol file: 158664-54-1.mol

Synonyms:4,5-Diazaspiro[2.4]hept-4-ene-6-carboxylicacid,6-methyl-,methylester(9CI)

Chemical Property of 4,5-Diazaspiro[2.4]hept-4-ene-6-carboxylicacid,6-methyl-,methylester(9CI)

Chemical Property:

• PSA: 51.02000
• LogP: 0.17780

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-Diazaspiro[2.4]hept-4-ene-6-carboxylicacid,6-methyl-,methylester(9CI)

There total 3 articles about 4,5-Diazaspiro[2.4]hept-4-ene-6-carboxylicacid,6-methyl-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) + Cyclopropylamine (765-30-0) → 6-methoxycarbonyl-6-methyl-4,5-diazaspiro<2,4>hept-4-ene (158664-54-1)

Guidance literature:

With n-Butyl nitrite; benzoic acid; In chloroform; at 5 ℃; for 264h;

DOI:10.1023/B:RUCB.0000035655.90713.05

Reference yield: 24.0%

methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) + Cyclopropylamine (765-30-0) + Trimethylacetic acid (75-98-9) → allyl t-butyl carbonate (15784-26-6) + 6-methoxycarbonyl-6-methyl-4,5-diazaspiro<2,4>hept-4-ene (158664-54-1) + cyclopropyl pivalate

Guidance literature:

With n-Butyl nitrite; In chloroform; at 5 ℃; for 16h; Title compound not separated from byproducts;

DOI:10.1023/B:RUCB.0000035655.90713.05

Reference yield:

N-nitroso-N-cyclopropylurea (10575-90-3) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → 6-methoxycarbonyl-6-methyl-4,5-diazaspiro<2,4>hept-4-ene (158664-54-1)

Guidance literature:

Alkaline conditions;

DOI:10.1021/acs.joc.8b00725

upstream raw materials:

methacrylic acid methyl ester

Cyclopropylamine

Trimethylacetic acid

N-nitroso-N-cyclopropylurea

Downstream raw materials:

1-methoxycarbonyl-1-methylcarbonylspiropentane

6-amino-6-methyl-4-aza-spiro[2.4]heptan-5-one