methyl 1-(phenylsulfonyl)-3-(trifluoromethyl )-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: methyl 1-(phenylsulfonyl)-3-(trifluoromethyl )-1H-pyrrole-2-carboxylate
• CAS No.: 1403942-38-0
• Molecular Formula: C₁₃H₁₀F₃NO₄S
• Molecular Weight: 333.288
• Mol file: 1403942-38-0.mol

Synonyms:methyl 1-(phenylsulfonyl)-3-(trifluoromethyl )-1H-pyrrole-2-carboxylate

Chemical Property of methyl 1-(phenylsulfonyl)-3-(trifluoromethyl )-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of methyl 1-(phenylsulfonyl)-3-(trifluoromethyl )-1H-pyrrole-2-carboxylate

There total 6 articles about methyl 1-(phenylsulfonyl)-3-(trifluoromethyl )-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) + methyl 3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate (1192217-76-7) → methyl 1-(phenylsulfonyl)-3-(trifluoromethyl )-1H-pyrrole-2-carboxylate (1403942-38-0)

Guidance literature:

2,2-difluoro-2-(fluorosulfonyl)acetate; methyl 3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate; With copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 80 ℃; Inert atmosphere;

With 5%-palladium/activated carbon; hydrogen; In ethanol;

DOI:10.1016/j.bmcl.2018.02.013

Reference yield: 18.0%

2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) + methyl 3-iodo-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate (1403942-39-1) → methyl 1-(phenylsulfonyl)-3-(trifluoromethyl )-1H-pyrrole-2-carboxylate (1403942-38-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Inert atmosphere;

Reference yield:

2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) + methyl 3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate (1192217-76-7) → methyl 1-(phenylsulfonyl)-3-(trifluoromethyl )-1H-pyrrole-2-carboxylate (1403942-38-0) + methyl 3-(perfluoroethyl)-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate

Guidance literature:

With copper(l) iodide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; at 100 ℃; for 48h; Inert atmosphere;

upstream raw materials:

2,2-difluoro-2-(fluorosulfonyl)acetate

methyl 3-iodo-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate

methyl 3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate

1-(benzenesulfonyl)-3-bromo-1H-pyrrole