(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone

Base Information

Chemical Name:(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone
CAS No.:1430077-87-4
Molecular Formula:C₄₁H₆₂O₃Si₂
Molecular Weight:659.112
Hs Code.:

Synonyms:(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone

Suppliers and Price of (3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone

Chemical Property:

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Technology Process of (3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone

There total 4 articles about (3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1430077-85-2
(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-hydroxyisoandrosterone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1430077-87-4
(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol4004993

Reference yield:

: 481-29-8
Epiandrosterone

: 1430077-87-4
(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone

Guidance literature:: Multi-step reaction with 4 steps

1: copper(ll) bromide / methanol / Reflux; Inert atmosphere

2: 1H-imidazole; dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: water; sodium hydroxide / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4: 1H-imidazole; dmap / dichloromethane / 12 h / 20 °C

With 1H-imidazole; dmap; water; sodium hydroxide; copper(ll) bromide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol4004993

Reference yield:

: C₃₅H₄₇BrO₂Si

: 1430077-87-4
(3S,16R)-3-(tert-butyldiphenylsilyloxy)-16-((tert-butyldimethylsilyl)oxy)isoandrosterone

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2: 1H-imidazole; dmap / dichloromethane / 12 h / 20 °C

With 1H-imidazole; dmap; water; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol4004993