3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane

Base Information

Chemical Name:3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane
CAS No.:951743-84-3
Molecular Formula:C₂₆H₃₀N₄O₄
Molecular Weight:462.549
Hs Code.:

Synonyms:3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane

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Chemical Property of 3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane

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Technology Process of 3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane

There total 10 articles about 3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₆ClN₃O₃

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 951743-84-3
3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane

Guidance literature:: With triethylamine; In tetrahydrofuran; at 60 ℃; for 6h;

Reference yield:

: 951745-26-9
benzyl 3-formyl-8-azabicyclo[3.2.1]octane-8-carboxylate

: 951743-84-3
3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 1.5 h / 20 °C

2: methanol / 20 h

3: hydrogen / ASCA-2 / methanol; ethyl acetate / 2 h

4: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

5: triethylamine / tetrahydrofuran / 6 h / 60 °C

With hydrogen; triethylamine; ASCA-2; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

: 28957-72-4
N-benzyltropinone

: 951743-84-3
3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogen; acetic acid / ASCA-2 / 5 h / 20 °C / 760.05 Torr

2.1: sodium hydrogencarbonate / tetrahydrofuran; water / 1 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -15 °C

3.2: 15 h / -15 - 20 °C

4.1: hydrogenchloride / tetrahydrofuran; water / 5 h

5.1: methanol / 1.5 h / 20 °C

6.1: methanol / 20 h

7.1: hydrogen / ASCA-2 / methanol; ethyl acetate / 2 h

8.1: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

9.1: triethylamine / tetrahydrofuran / 6 h / 60 °C

With hydrogenchloride; potassium tert-butylate; hydrogen; sodium hydrogencarbonate; acetic acid; triethylamine; ASCA-2; In tetrahydrofuran; methanol; water; ethyl acetate;