1,1-Dimethylethyl (4S)-5-oxo-3-[(phenylmethoxy)carbonyl]-4-oxazolidineacetate

Base Information

Chemical Name:1,1-Dimethylethyl (4S)-5-oxo-3-[(phenylmethoxy)carbonyl]-4-oxazolidineacetate
CAS No.:23632-69-1
Molecular Formula:C₁₇H₂₁NO₆
Molecular Weight:335.357
Hs Code.:
European Community (EC) Number:607-254-7
DSSTox Substance ID:DTXSID201139226

Synonyms:DTXSID201139226;1,1-Dimethylethyl (4S)-5-oxo-3-[(phenylmethoxy)carbonyl]-4-oxazolidineacetate;23632-69-1

Suppliers and Price of 1,1-Dimethylethyl (4S)-5-oxo-3-[(phenylmethoxy)carbonyl]-4-oxazolidineacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1-Dimethylethyl (4S)-5-oxo-3-[(phenylmethoxy)carbonyl]-4-oxazolidineacetate

Chemical Property:

Vapor Pressure:1.12E-09mmHg at 25°C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:335.13688739
Heavy Atom Count:24
Complexity:478

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CC1C(=O)OCN1C(=O)OCC2=CC=CC=C2
Isomeric SMILES:CC(C)(C)OC(=O)C[C@H]1C(=O)OCN1C(=O)OCC2=CC=CC=C2

Technology Process of 1,1-Dimethylethyl (4S)-5-oxo-3-[(phenylmethoxy)carbonyl]-4-oxazolidineacetate

There total 4 articles about 1,1-Dimethylethyl (4S)-5-oxo-3-[(phenylmethoxy)carbonyl]-4-oxazolidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 507-19-7
t-butyl bromide

: 23632-66-8
(4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one

: 23632-69-1
(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidine acetic acid tert-butyl ester

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In N,N-dimethyl acetamide; at 55 ℃; for 24h;
DOI:10.1016/S0040-4039(00)60139-9

Reference yield:

: 1152-61-0
N-Cbz-L-Asp

: 23632-69-1
(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidine acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.4 g / TsOH / toluene / 1 h / Heating

2: 1.) pyridine, dimethylaminopyridine, 2.) 3-dimethylaminopropylamine, / 1.) t-BuOH, EtOAc, 15 to 20 deg C, 16-20 h, 2.) t-BuOH, EtOAc, 15 min

With pyridine; dmap; toluene-4-sulfonic acid; 1-amino-3-(dimethylamino)propane; In toluene;