5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

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Chemical Name:5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide
CAS No.:1402888-94-1
Molecular Formula:C₂₂H₃₂N₂O₃S
Molecular Weight:404.574
Hs Code.:

Synonyms:5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

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Chemical Property of 5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

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Technology Process of 5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

There total 9 articles about 5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1402890-07-6
3-tert-butyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1402889-86-4
5-Bromo-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

: 1402888-94-1
5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 20 ℃; for 7h; Reflux; Inert atmosphere;

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 1402888-94-1
5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide / N,N-dimethyl-formamide / 3 h / 80 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Sealed vial

3: boron tribromide / dichloromethane / 2 h / 0 °C / Inert atmosphere

4: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 7 h / 20 °C / Reflux; Inert atmosphere

With copper(l) iodide; potassium acetate; boron tribromide; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki Coupling / 4: Suzuki Coupling;

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 1402888-94-1
5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

1.2: 50 °C

2.1: chlorosulfonic acid / 36 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / ethanol; water / Reflux

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / -78 °C

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 7 h / 20 °C / Reflux; Inert atmosphere

With hydrogenchloride; chlorosulfonic acid; N-Bromosuccinimide; potassium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;