(1S,2R,4R,S_S)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide

Base Information

• Chemical Name: (1S,2R,4R,S_S)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide
• CAS No.: 253665-36-0
• Molecular Formula: C₂₁H₃₃NO₃SSi
• Molecular Weight: 407.649

Synonyms:(1S,2R,4R,S_S)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide

Chemical Property of (1S,2R,4R,S_S)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,4R,S_S)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide

There total 2 articles about (1S,2R,4R,S_S)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-methoxy-benzaldehyde (123-11-5) + (1S,2R,4R,SS)-7,7-dimethyl-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide (253665-34-8) → (1S,2R,4R,SS)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide (253665-36-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -20 - 20 ℃;

DOI:10.1021/jo990913f

Reference yield:

(1S,5R,7R,SS)-10,10-dimethyl-4-oxo-3-thiatricyclo[5.2.1.01,5]decane-3-oxide (178455-82-8) → (1S,2R,4R,SS)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide (253665-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LiHMDS / tetrahydrofuran / 3 h / -30 °C

1.2: 40 percent / tetrahydrofuran / 2 h / -30 °C

2.1: 86 percent / n-BuLi / tetrahydrofuran; hexane / -20 - 20 °C

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; 1.1: Ring cleavage / 1.2: Substitution / 2.1: Condensation;

DOI:10.1021/jo990913f

Reference yield:

1-phenoxy-1-trimethylsilyloxyethene (111061-31-5) + (1S,2R,4R,SS)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide (253665-36-0) → methyl 3-amino-2,2-dimethyl-3-(4-methoxyphenyl)propanoate

Guidance literature:

1-phenoxy-1-trimethylsilyloxyethene; (1S,2R,4R,S_S)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -70 ℃; for 6h;

With water; In dichloromethane; at 20 ℃; for 0.5h;

With water; sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jo990913f

upstream raw materials:

4-methoxy-benzaldehyde

(1S,2R,4R,S_S)-7,7-dimethyl-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide

(1S,5R,7R,S_S)-10,10-dimethyl-4-oxo-3-thiatricyclo[5.2.1.0^1,5]decane-3-oxide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 253665-36-0 (1S,2R,4R,S_S)-7,7-dimethyl-N-(4-methoxyphenyl)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send