[3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal

Base Information

Chemical Name:[3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal
CAS No.:243978-61-2
Molecular Formula:C₃₀H₄₄O₄S₂Si
Molecular Weight:560.894
Hs Code.:

Synonyms:[3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal

Suppliers and Price of [3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal

There total 1 articles about [3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 95452-06-5
tert-butyl(1,3-dithian-2-yl)dimethylsilane

: 157363-85-4
1,2:5,6-Dianhydro-3,4-di-O-benzyl-D-mannitol

: [3R,4S,5R,6S]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-6-hydroxymethyl-3,4,5-trihydroxycyclohexan-1-one 1,3-propanedithioketal

: 243978-61-2
[3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal

Guidance literature:: tert-butyl(1,3-dithian-2-yl)dimethylsilane; With n-butyllithium; dibutylmagnesium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;

1,2:5,6-Dianhydro-3,4-di-O-benzyl-D-mannitol; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 20 ℃;

Reference yield: 100.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 243978-61-2
[3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal

: 243978-67-8
[3R,4S,5S,6R]-4,5-dibenzyloxy-3,6-di-tert-butyl(dimethyl)silyloxycycloheptan-1-one 1,3-propanedithioketal

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 70 ℃; for 24h;
DOI:10.1016/j.tet.2003.09.049

Reference yield:

: 243978-61-2
[3R,4S,5R,6R]-4,5-di-O-benzyl-3-O-tert-butyl(dimethyl)silyl-3,4,5,6-tetrahydroxycycloheptan-1-one 1,3-propanedithioketal

: 243978-65-6
[3R,4S,5S,6R]-4,5-dibenzyloxy-3,6-di-tert-butyl(dimethyl)silyloxycycloheptan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / imidazole / dimethylformamide / 24 h / 70 °C

2: 77 percent / N-bromosuccinimide / acetone; H₂O / 0.5 h / -25 °C

With 1H-imidazole; N-Bromosuccinimide; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2003.09.049