tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate
CAS No.:1401533-08-1
Molecular Formula:C₃₁H₃₂ClN₃O₃S
Molecular Weight:562.132
Hs Code.:

Synonyms:tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate

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Technology Process of tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 21815-91-8
3-chlorobenzo[b]thiophen-2-carbonyl chloride

: 1401533-26-3
tert-butyl 4-[(3-pyridin-4-ylbenzyl)amino]piperidine-1-carboxylate

: 1401533-08-1
tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.08.026

Reference yield:

: 13035-19-3
4-aminopiperidine

: 1401533-08-1
tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 5.5 h / Inert atmosphere; Reflux

2: toluene / 14.08 h / 0 - 20 °C / Inert atmosphere

3: potassium hydrogensulfate; water / tert-butyl methyl ether / 4 h / 20 °C / Inert atmosphere

4: magnesium sulfate; sodium tetrahydroborate / ethanol / 8 h / 80 °C / Inert atmosphere

5: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; potassium hydrogensulfate; water; magnesium sulfate; triethylamine; In ethanol; dichloromethane; tert-butyl methyl ether; toluene;
DOI:10.1016/j.bmc.2012.08.026

Reference yield:

: 1044183-50-7
4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester

: 1401533-08-1
tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydrogensulfate; water / tert-butyl methyl ether / 4 h / 20 °C / Inert atmosphere

2: magnesium sulfate; sodium tetrahydroborate / ethanol / 8 h / 80 °C / Inert atmosphere

3: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; potassium hydrogensulfate; water; magnesium sulfate; triethylamine; In ethanol; dichloromethane; tert-butyl methyl ether;
DOI:10.1016/j.bmc.2012.08.026