3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide

Base Information

Chemical Name:3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide
CAS No.:1401532-90-8
Molecular Formula:C₂₆H₂₄ClN₃OS
Molecular Weight:462.015
Hs Code.:

Synonyms:3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide

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Chemical Property of 3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide

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Technology Process of 3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide

There total 8 articles about 3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1401533-08-1
tert-butyl 4-{[(3-chlorobenzo[b]thiophene-2-yl)carbonyl](3-pyridin-4-ylbenzyl) amino}piperidine-1-carboxylate

: 1401532-90-8
3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2012.08.026

Reference yield:

: 13035-19-3
4-aminopiperidine

: 1401532-90-8
3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 5.5 h / Inert atmosphere; Reflux

2: toluene / 14.08 h / 0 - 20 °C / Inert atmosphere

3: potassium hydrogensulfate; water / tert-butyl methyl ether / 4 h / 20 °C / Inert atmosphere

4: magnesium sulfate; sodium tetrahydroborate / ethanol / 8 h / 80 °C / Inert atmosphere

5: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

6: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; potassium hydrogensulfate; water; magnesium sulfate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; tert-butyl methyl ether; toluene;
DOI:10.1016/j.bmc.2012.08.026

Reference yield:

: 1029643-92-2
N-phenylmethylidenepiperidinyl-4-amine

: 1401532-90-8
3-chloro-N-piperidin-4-yl-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 14.08 h / 0 - 20 °C / Inert atmosphere

2: potassium hydrogensulfate; water / tert-butyl methyl ether / 4 h / 20 °C / Inert atmosphere

3: magnesium sulfate; sodium tetrahydroborate / ethanol / 8 h / 80 °C / Inert atmosphere

4: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; potassium hydrogensulfate; water; magnesium sulfate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; tert-butyl methyl ether; toluene;
DOI:10.1016/j.bmc.2012.08.026