3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one

Base Information

Chemical Name:3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one
CAS No.:898808-89-4
Molecular Formula:C₂₉H₃₁NO₇
Molecular Weight:505.568
Hs Code.:

Synonyms:3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one

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Chemical Property of 3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one

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Technology Process of 3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one

There total 6 articles about 3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 898808-87-2
3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2H-isoquinolin-1-one

: 74-88-4
methyl iodide

: 898808-89-4
3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one

Guidance literature:: 3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2H-isoquinolin-1-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 0 - 60 ℃;
DOI:10.1248/cpb.54.476

Reference yield:

: 898808-83-8
4-benzyloxy-2-formyl-5-methoxybenzonitrile

: 898808-89-4
3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / NaBH₄; acetic acid / 2 h / 20 °C

2.1: 93 percent / diisopropylethylamine / CH₂Cl₂ / 0 °C

3.1: 30 percent / n-BuLi / tetrahydrofuran / 4 h / -70 °C

4.1: NaH / tetrahydrofuran / 1 h / 0 °C

4.2: 70 percent / tetrahydrofuran / 0 - 60 °C

With sodium tetrahydroborate; n-butyllithium; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.54.476

Reference yield:

: 2-(5-(benzyloxy)-2-bromo-4-methoxyphenyl)-1,3-dioxolane

: 898808-89-4
3-(4-benzyloxy-5-methoxy-2-methoxymethoxymethylphenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 81 percent / dimethylformamide / 3 h / Heating

2.1: 83 percent / aq. HCl / 0.25 h / 50 - 60 °C

3.1: 88 percent / NaBH₄; acetic acid / 2 h / 20 °C

4.1: 93 percent / diisopropylethylamine / CH₂Cl₂ / 0 °C

5.1: 30 percent / n-BuLi / tetrahydrofuran / 4 h / -70 °C

6.1: NaH / tetrahydrofuran / 1 h / 0 °C

6.2: 70 percent / tetrahydrofuran / 0 - 60 °C

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.54.476